Testing liver cell injections for advanced cirrhosis
Part of Digestive system clinical trials.
This trial tests if injecting donated liver cells into the main artery feeding the liver can help people with decompensated cirrhosis. It aims to see if this treatment is safe and might improve liver function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with decompensated cirrhosis (liver failure with complications like fluid buildup or confusion).
- Your liver function score (Child-Pugh) is between 7 and 12, meaning moderate to severe liver damage.
- You are well enough to do daily activities without much help (ECOG 0-2 or Karnofsky score over 60).
- If you have hepatitis B or C, your virus levels must be low (below 1000 IU/mL for B, below 15 IU/mL for C). For alcohol-related cirrhosis, you must have been sober for at least 6 months.
- Your liver enzymes (ALT) are no more than 3 times the normal maximum.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new cell injection called HCL001 for people with decompensated cirrhosis (advanced liver scarring causing complications). The goal is to see if it's safe and helps improve liver function. It may be an option if you've tried standard treatments and meet specific health criteria.
This trial tests whether giving a combination of two medicines (GCSF and Darbepoetin) one time or multiple times can help people with early-stage liver cirrhosis who have started to develop complications. The goal is to see if this treatment can improve liver function and delay the need for a transplant.
This trial tests umbilical-cord stem cells to see if they can improve outcomes in people with decompensated (worsening) cirrhosis. You may be considered if your liver disease is moderate to severe (MELD 15–30) and you do not have certain high-risk problems right now.
This study tests an injection called CUD005 for people with advanced liver cirrhosis that is causing complications. The goal is to see if it is safe and can help improve liver function.
This trial tests an injection of stem cells from donated umbilical cords to see if it can help people with advanced liver scarring from hepatitis B. You may be able to join if standard treatments haven’t helped enough and you aren’t able to get a liver transplant.
This Phase 3 trial tests whether a cell medicine called Cellgram-LC, delivered through a catheter into the liver artery, is safer and works better for people with alcoholic cirrhosis. It may help improve outcomes in people with more advanced liver scarring.
Hear when a new Decompensated Cirrhosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.