Phage therapy for pouchitis in ulcerative colitis
Part of Digestive system clinical trials.
This study tests an oral treatment made from bacteria-killing viruses (phages) for pouchitis, a common complication after surgery for ulcerative colitis. The goal is to see if it safely reduces inflammation and symptoms in the pouch.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have ulcerative colitis and have had the pouch surgery (IPAA) completed at least 3 months ago.
- You have pouchitis with a symptom score of 5 or higher.
- Your stool test shows a specific bacteria (MTB or Aeromonas aerolysin).
- You have not used antibiotics in the past 3 months or probiotics recently.
- You are not pregnant or breastfeeding, and have no major heart, immune, or cancer conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
This study looks at how tryptophan, an amino acid found in foods like turkey and milk, might affect the treatment of pouchitis, which is inflammation of the pouch created after ulcerative colitis surgery. It aims to see if adding tryptophan to standard treatment with antibiotics and probiotics could help.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
This study tests whether a common anti-inflammatory medicine, called 5-ASA, can help prevent pouchitis (an inflammation of the surgically created pouch) in people with ulcerative colitis who have had restorative surgery.
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