Tryptophan and pouchitis treatment study
Part of Digestive system clinical trials.
This study looks at whether adding tryptophan, a natural substance found in food, can help improve treatment for pouchitis, which is inflammation in a surgically created internal pouch. It aims to see if it makes antibiotics and probiotics work better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with pouchitis (inflammation in your ileal pouch).
- Your doctor has decided you need treatment with antibiotics and probiotics.
- You are 18 years or older.
- You agree to take part in the study and sign a consent form.
- You do not have major surgery planned during the study.
- You are not at high risk for malnutrition (using standard screening).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
This trial tests whether a medicine applied to the pouch after surgery can prevent pouchitis (inflammation of the pouch) in people with ulcerative colitis who have had their colon removed and a pouch created. It may help avoid the discomfort and complications of pouchitis.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This study tests a medicine called vedolizumab to see if it is safe and helps children and teenagers with chronic pouchitis (inflammation in the pouch after colon removal). It is for kids who have not had good results with other treatments.
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