Testing guselkumab with antibiotics for chronic pouchitis
Treatments studied
Part of Digestive system clinical trials.
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have had your colon and rectum removed because of ulcerative colitis, resulting in a J-pouch internal pouch.
- You have had at least 2 episodes of pouchitis in the past year that needed treatment, or you have been on antibiotics for pouchitis for at least 4 weeks without success.
- You agree to take ciprofloxacin (or metronidazole if you cannot take cipro) for the first 4 weeks of the study.
- You have not received a drug like Stelara, Skyrizi, or any other IL-12/23 blocker in the past.
- You do not have a serious infection, active tuberculosis, or other health conditions that would make the study unsafe for you.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medicine called vedolizumab to see if it is safe and helps children and teenagers with chronic pouchitis (inflammation in the pouch after colon removal). It is for kids who have not had good results with other treatments.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This trial tests whether a medicine applied to the pouch after surgery can prevent pouchitis (inflammation of the pouch) in people with ulcerative colitis who have had their colon removed and a pouch created. It may help avoid the discomfort and complications of pouchitis.
This trial tests if mirikizumab can help people with chronic inflammation of the pouch (a surgically created internal reservoir) that doesn't respond well to antibiotics or acts like Crohn's disease. It aims to see if the drug can reduce symptoms like urgency, pain, and bleeding.
This early-phase study tests fecal microbiota transplant (a stool-based treatment) to improve chronic pouchitis symptoms in adults after UC-related surgery. It may help by changing gut bacteria, especially for people who need ongoing antibiotics or keep having flare-ups.
This trial tests whether the antibiotic rifaximin can prevent pouchitis from coming back after a first episode. It is for people who had ulcerative colitis, have a J-pouch, and developed pouchitis within the first year after their final surgery.
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