CAR T-cell therapy for CD70-positive blood cancers in children
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a special immune cell therapy (CAR T-cells) that targets a protein called CD70 on blood cancer cells. It is for children and young adults up to age 21 whose cancer has come back or hasn't gotten better with other treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- The patient must be 21 years old or younger
- The blood cancer (like AML, ALL, MDS, or lymphoma) must have come back or not responded to treatment and test positive for CD70
- For B-cell ALL or lymphoma, the cancer must be CD19 negative or the patient must be unable to get CD19-directed therapy — for example, after a second relapse or after a stem cell transplant
- The patient must have a life expectancy greater than 12 weeks and be well enough to be up and about for at least half the day
- If the patient has had a stem cell transplant before, they must be fully healed from it with no active graft-versus-host disease and no donor lymphocyte infusion in the last 28 days
- The patient must have a stem cell donor identified
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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