Comparing heart imaging methods for a procedure to prevent stroke
Part of Heart & circulation clinical trials.
This trial is testing two ways to guide a procedure that closes a small pouch in the heart to lower the risk of stroke in people with atrial fibrillation. The goal is to see if one method is as good or better than the other.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have atrial fibrillation that is not caused by a heart valve problem, and it comes and goes or is ongoing.
- Your doctor has determined you have a high risk of stroke based on a scoring system like CHADS2 or CHA2DS2-VASc.
- You are eligible for blood thinners but have a reason to seek an alternative, like the left atrial appendage closure procedure.
- You can have a CT scan or a special ultrasound of your heart before the procedure.
- You are willing and able to follow the study plan and give written consent.
- You are 18 years or older.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
This study compares two imaging methods (TEE and CCTA) used before a procedure to close a small pouch in the heart, which helps prevent strokes in people with atrial fibrillation. Participants will be randomly assigned to one method, and both groups will be checked after 3 months to see which imaging works better.
This study compares two ways of closing a small pouch in the heart (the left atrial appendage) to help prevent strokes in people with atrial fibrillation (an irregular heartbeat). One method is less invasive, and the study aims to see if it is as safe and effective as the standard approach.
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
This study looks at how different imaging tests can help guide a procedure that closes off the left atrial appendage to reduce stroke risk. It may help doctors choose the safest approach during the procedure.
This study compares two devices (LAmbre and AMPLATZER Amulet) that are placed in the heart to prevent strokes in people with atrial fibrillation who cannot take blood thinners. If you join, you will be randomly assigned to get one of the two devices.
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