Clinical trials
Left Atrial Appendage Closure clinical trials
Below are recruiting left atrial appendage closure clinical trials, each written for real people, not researchers. We’re tracking 43 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04559243Recruiting
Left atrial appendage closure to prevent stroke in AF
This study tests whether closing a heart pocket called the left atrial appendage can lower future stroke or other clot-related events in people with atrial fibrillation. It’s mainly for people who have had a prior clot-related event or are at higher risk but may not be good candidates for long-term blood thinners.
Jinan, ShandongAges 18 years+ - NCT03445949RecruitingPhase 4
Best blood-thinner plan after a left heart device procedure
This trial compares which two medicines work best after a device closes off a part of the heart called the left atrial appendage. It may help reduce stroke risk while balancing bleeding risk after your procedure.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT06060912Recruiting
Comparing two heart devices to prevent stroke in atrial fibrillation
This study compares two devices (LAmbre and AMPLATZER Amulet) that are placed in the heart to prevent strokes in people with atrial fibrillation who cannot take blood thinners. If you join, you will be randomly assigned to get one of the two devices.
Munich, BavariaAges 18–100 - NCT05204212Recruiting
Heart procedure to close an atrial clot risk pouch in kidney failure
This trial tests a heart procedure that closes a part of the heart called the left atrial appendage to help prevent stroke in people with an irregular heartbeat (atrial fibrillation) and very advanced kidney disease. It’s mainly for patients who can take the needed blood-thinner medicines and who do not already have a clot in that pouch.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT06401616RecruitingPhase 4
Stopping blood thinners after heart surgery for atrial fibrillation
This trial tests whether it is safe for patients with atrial fibrillation to stop taking blood thinners after they have had heart surgery, including closure of the left atrial appendage. The goal is to see if these patients can avoid long-term medication without increasing the risk of stroke.
Copenhagen, Capital RegionAges 18 years+ - NCT07840365RecruitingPhase 3
Finding the best blood-thinner plan after a Watchman device procedure
This study tests which blood-thinner approach works best after a procedure to close a small heart pouch (left atrial appendage) with a Watchman device. It aims to prevent strokes while reducing bleeding risks.
Austin, TexasAges 18 years+ - NCT07815119Recruiting
Comparing two heart imaging methods before a stroke-prevention procedure
This study compares two imaging methods (TEE and CCTA) used before a procedure to close a small pouch in the heart, which helps prevent strokes in people with atrial fibrillation. Participants will be randomly assigned to one method, and both groups will be checked after 3 months to see which imaging works better.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05951101Recruiting
Device to close an irregular heartbeat heart pocket safely
This trial tests the Zenith system, a device that seals off a heart area called the left atrial appendage to reduce stroke risk in people with atrial fibrillation (AF). You may be eligible if you have AF and a doctor recommends LAA closure, and you can return for follow-up scans and visits.
Parkville, VictoriaAges 18 years+ - NCT04800913Recruiting
Imaging tests during left atrial appendage closure
This study looks at how different imaging tests can help guide a procedure that closes off the left atrial appendage to reduce stroke risk. It may help doctors choose the safest approach during the procedure.
BudapestAges 18 years+ - NCT03409159Recruiting
Left atrial appendage closure registry in Austria
This study keeps records of people who already had a procedure to close a part of the heart called the left atrial appendage in Austria. It helps doctors understand outcomes and safety for patients after the procedure.
GrazAges 18 years+ - NCT07575867Recruiting
Reduced Blood Thinner Strategy After Heart Device Closure
This trial tests whether patients who receive a special device to close a hole in the heart (to prevent stroke from irregular heartbeat) can safely take fewer blood-thinning medications afterward. The study compares taking a standard blood thinner for 3 months versus taking aspirin only, to see which approach works best with fewer bleeding risks.
MoscowAges 18 years+ - NCT07453940Enrolling by invitation
Closing off heart pouch with or without pulsed energy in atrial fibrillation
This study tests if adding a special energy treatment (pulsed field ablation) to a standard heart pouch closure is safe and works better for people with persistent atrial fibrillation who have few symptoms but a high risk of stroke.
Hangzhou, ZhejiangAges 18 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07385599Recruiting
Study of a new heart device for atrial fibrillation patients
This trial tests a new device called LAmbre™ II that closes off a part of the heart called the left atrial appendage to help prevent strokes in people with atrial fibrillation who cannot take blood thinners.
ShatinAges 18 years+ - NCT07361445Recruiting
Study of a device to help access the heart during ablation
This trial tests a new device to help doctors safely enter the left side of your heart during a procedure called ablation. If you are already scheduled for an ablation or a combined ablation and left atrial appendage closure, this study may be an option.
Jonesboro, ArkansasAges 18 years+ - NCT07360899Recruiting
Closing the left atrial appendage during heart surgery to prevent stroke
This trial tests if closing the left atrial appendage with a special stitch during planned heart surgery can help prevent strokes in people with atrial fibrillation. If you already need heart surgery, this extra step may reduce your future stroke risk.
Kamenitz, VojvodinaAges 18 years+ - NCT07349121Recruiting
Testing the Farapulse and Watchman devices together
This trial is for people who need both a special heart treatment called pulsed field ablation (FARAPULSE) and a device to close off a small pouch in the heart (WATCHMAN FLX Pro or WATCHMAN FLX) to prevent strokes. The study will see how well both procedures work when done together.
AalstAges 18 years+ - NCT06869811Recruiting
Stroke prevention after failed blood thinners
This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
Barcelona, BarcelonaAges 18–95 - NCT07278869Recruiting
Study of Append system for atrial fibrillation patients
This trial tests a new device, the Append System, to close off the left atrial appendage (a small pouch in the heart) in people with atrial fibrillation. The goal is to reduce stroke risk without needing long-term blood thinners.
Jonesboro, ArkansasAges 18 years+ - NCT07260474Recruiting
Closing a heart pocket to prevent strokes in atrial fibrillation
This study compares two similar devices that close off a small pocket in the heart to reduce stroke risk in people with atrial fibrillation who cannot take blood thinners safely. The goal is to see which device works better and is safer.
Fuencarral-El PardoAges 18 years+ - NCT07236398Enrolling by invitation
Modified left atrial maze procedure for atrial fibrillation
This trial tests a modified maze procedure to treat atrial fibrillation during heart surgery. It may help patients with AFib who are already scheduled for cardiac surgery.
Toulouse, French (France)Ages 18 years+ - NCT07125417RecruitingPhase 4
Blood thinner comparison after left atrial appendage closure
This study compares two approaches after a left atrial appendage closure (LAAC) procedure: taking no blood thinner versus taking just one antiplatelet medication. It aims to see which option is safer for people with atrial fibrillation who are at risk for bleeding.
Nagoya, Aichi-kenAges Any age - NCT06984731Recruiting
Same-day ablation and WATCHMAN closure for AFib
This study tests whether doing a common AFib procedure (radiofrequency ablation) is safe and effective at the same time as closing off the left atrial appendage with the WATCHMAN FLX device. It's for people with nonvalvular atrial fibrillation who are already candidates for both treatments.
Nantong, JiangsuAges 18–80 - NCT06802965Enrolling by invitation
Shanghai atrial fibrillation patient registry study
This study tracks people in Shanghai who have been diagnosed with atrial fibrillation (AF, a heart rhythm condition). By joining a registry, researchers can learn more about how AF is managed over time in the local population.
ShanghaiAges Any age
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Common questions
- Are there clinical trials for left atrial appendage closure?
- Yes. Clin2 currently lists 43 recruiting left atrial appendage closure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a left atrial appendage closure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a left atrial appendage closure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.