Deep brain stimulation for severe obsessive-compulsive disorder
Part of Mental health clinical trials.
This trial tests a treatment called deep brain stimulation (DBS), which uses a device placed in the brain to send electrical signals that may help control OCD symptoms. It is for adults with OCD that has not improved after trying several standard treatments, such as SSRIs, clomipramine, and therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with obsessive-compulsive disorder (OCD) by a doctor.
- You have tried at least two different SSRI medications (like Lexapro or Zoloft) for at least 3-6 months each, and they did not work well.
- You have tried the medication clomipramine at the maximum dose for 3-6 months, and it did not help.
- You have also tried cognitive behavioral therapy (CBT) for at least 6 months, or an atypical antipsychotic medication for 3 months, without enough improvement.
- You have not had any prior treatments like electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or deep brain stimulation.
- You are not currently at high risk of suicide.
- You can communicate effectively with the study team and provide written consent.
- You do not have other psychotic disorders, a history of traumatic brain injury, or intracranial or cardiovascular stents.
- You are not pregnant, breastfeeding, or planning to become pregnant during the study without using reliable contraception.
- You have not participated in another clinical trial in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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