Testing CM326 for chronic sinusitis with nasal polyps
Treatments studied
Part of Ear, nose & throat clinical trials.
This study tests a new medicine called CM326 for people with chronic sinusitis and nasal polyps (growths in the nose). It may help if you still have symptoms despite using steroid sprays or if you cannot take steroids.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old
- You have had nasal polyps treated with steroid pills or shots in the last 2 years, or you cannot take steroids, or you had surgery for nasal polyps in the last 6 months
- You are not allergic to the nasal spray mometasone furoate or the study drug CM326
- You do not have a severely deviated septum blocking one nostril, or certain types of sinus infections or growths
- You do not have serious health problems like major liver or kidney disease, or cancer in your nasal cavity
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This early-stage trial tests a new nasal spray combining stem cell-derived material, an antibiotic, and an enzyme to treat chronic sinus infections caused by a specific bacteria. The goal is to reduce inflammation and infection in people who have had symptoms for over 3 months.
This is a follow-up study for people who already participated in an earlier CM512 trial for chronic rhinosinusitis with nasal polyps—a condition where growths develop inside the nose and sinuses. The study tests whether CM512 continues to help reduce these polyps.
This study is looking for markers in the blood that can predict how well certain biologic drugs work for people with chronic sinusitis and nasal polyps. It may help find the right treatment for you if your symptoms are not controlled with standard sprays or after surgery.
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