Predicting biologic treatment response in chronic sinusitis with nasal polyps
Treatments studied
Part of Ear, nose & throat, Immune system & allergy clinical trials.
This study is testing whether certain markers in your blood can predict how well biologic injections (medicines that reduce inflammation) will work for chronic sinusitis with nasal polyps. You'll continue your regular nasal spray and may receive a biologic or a placebo (a shot with no medicine) to see if it improves your symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have nasal polyps on both sides of your nose that are causing noticeable symptoms.
- Within the past 2 years, you must have needed steroid pills for your nasal polyps, or you cannot take steroid pills due to side effects or other reasons, or you had nasal polyp surgery more than 6 months ago.
- You must have been using a daily steroid nasal spray (like fluticasone) at a steady dose for at least the past 4 weeks.
- You must have had symptoms like stuffy nose, trouble smelling, or a runny nose for at least the past 4 weeks.
- You must not have had certain biologic treatments within the last 10 weeks, or certain other medicines within the last 8 weeks.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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