Clot removal for very large strokes
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a procedure to remove a large blood clot in the brain (mechanical thrombectomy) for people who have a very large stroke. It aims to see if removing the clot can improve recovery, even for those with severe strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older (if 80 or older, you must have been able to do all daily activities independently before the stroke).
- The stroke happened within the last 6 hours, or if longer, a special MRI shows the stroke is still early.
- A blockage in a major artery in the neck or brain (like the internal carotid artery or middle cerebral artery) is confirmed by imaging.
- The stroke is very large, either showing a low score (0-2) on a CT scan called ASPECTS or the damaged area is at least 100 ml.
- There is no bleeding in the brain, and the stroke is not causing the brain to swell or shift.
- You are able to sign a consent form (or a family member can sign for you).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
This trial tests a procedure called endovascular thrombectomy (clot removal through a catheter) for people with very large strokes. It aims to see if removing the clot can help even when a large part of the brain is already damaged.
This trial tests if removing a large blood clot from the brain up to 3 days after a stroke improves recovery compared to standard medical care alone. It is for patients who have a severe stroke and are otherwise healthy enough for the procedure.
This trial tests whether removing a blood clot from a large brain artery is better than standard medical care for people who have a mild stroke (NIHSS score 2-5) but still have symptoms like trouble speaking, weakness, or confusion. It is for patients who can be treated within 24 hours of their last known well time.
This trial tests whether giving a clot-busting medication (tenecteplase) intravenously before mechanical thrombectomy—a procedure to physically remove a large blood clot from the brain—improves recovery better than thrombectomy alone in patients with large ischemic strokes.
This trial tests whether removing a blood clot from a large brain artery (using a catheter through the groin) can help people with mild stroke symptoms. It is for patients whose stroke started within the last 24 hours and who have a blockage in the front part of the brain's blood supply.
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