Clot removal for very large strokes
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a procedure to remove a large blood clot in the brain (mechanical thrombectomy) for people who have a very large stroke. It aims to see if removing the clot can improve recovery, even for those with severe strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older (if 80 or older, you must have been able to do all daily activities independently before the stroke).
- The stroke happened within the last 6 hours, or if longer, a special MRI shows the stroke is still early.
- A blockage in a major artery in the neck or brain (like the internal carotid artery or middle cerebral artery) is confirmed by imaging.
- The stroke is very large, either showing a low score (0-2) on a CT scan called ASPECTS or the damaged area is at least 100 ml.
- There is no bleeding in the brain, and the stroke is not causing the brain to swell or shift.
- You are able to sign a consent form (or a family member can sign for you).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a procedure called endovascular thrombectomy (clot removal through a catheter) for people with very large strokes. It aims to see if removing the clot can help even when a large part of the brain is already damaged.
This trial compares two ways of removing a blood clot from a large artery in the brain during an ischemic stroke. It might help you by finding out which method restores blood flow more safely and effectively.
This trial tests if removing a large blood clot from the brain up to 3 days after a stroke improves recovery compared to standard medical care alone. It is for patients who have a severe stroke and are otherwise healthy enough for the procedure.
This trial compares a procedure to remove a large blood clot from the brain (thrombectomy) with standard medical care for people who had a stroke 24 to 72 hours ago but still have some blood flow around the clot. It aims to see if the procedure can help improve recovery even when started later than usual.
This trial compares a procedure to remove a blood clot from a brain artery (endovascular therapy) with standard medicines alone, for people who had a large-vessel stroke more than 24 hours ago (up to 30 days). It aims to see if the procedure can still help improve recovery even after this longer time window, especially if symptoms are fluctuating or worsening.
This trial tests if removing clots from smaller arteries in the brain (not the main ones) helps people who had a stroke and can't get standard clot-busting medicine. It compares clot removal to usual care for strokes caused by these medium-sized vessel blockages.
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