Stem cell transplant for children and young adults without a perfect donor match
Part of Blood & lymphatic, Immune system & allergy clinical trials.
This trial provides a special type of stem cell transplant for people under 22 years old who don't have a fully matched sibling donor. It uses a method to remove certain cells from the donor's stem cells to reduce the risk of graft-versus-host disease, where the donor cells attack the patient's body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be under 22 years old.
- You must not have a fully matched sibling donor available.
- You need a donor who is either a haploidentical relative (half-matched) or an unrelated volunteer matched at 9 or 10 out of 10 HLA markers.
- Your vital organs (heart, lungs, kidneys, liver) must be working well enough to undergo the transplant.
- You must have a negative pregnancy test if you are able to become pregnant.
- Donors must be free of HIV, HTLV, and certain other infections, and must be willing to donate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies a type of stem cell transplant (bone marrow transplant) that uses a donor who is only half-matched to the patient, often a parent or sibling. It is for children and young adults with certain blood diseases, including sickle cell disease, thalassemia, bone marrow failure, and immune disorders. The transplant aims to replace the diseased blood-forming cells with healthy ones from the donor.
This trial tests a type of stem cell transplant that removes certain immune cells (alpha-beta T cells and CD19 B cells) from the donor cells. This may help prevent graft-versus-host disease and other complications in patients with blood cancers who do not have a matched sibling donor.
This trial offers a stem cell transplant using a half-matched family donor and/or cord blood for people with high-risk or hard-to-treat cancers or blood disorders. It aims to provide a treatment option when a perfectly matched donor is not available.
This trial studies a special donor stem cell transplant where the donor’s immune cells are reduced, aiming to lower harmful immune attacks after transplant. It may help children and young adults with certain high-risk blood cancers or rare bone marrow disorders.
This trial uses a stem cell transplant from a partially matched family member or unrelated donor to treat cancer and other blood disorders. Because the donor isn't fully matched, the transplant uses a special method to select certain stem cells (CD34-selected) to help reduce complications.
This expanded-access study offers a specific type of stem cell transplant preparation that removes certain immune cells (CD3 and CD19) from donor stem cells. It is for children who need a transplant but do not have a fully matched sibling donor and whose team cannot use the hospital’s usual matching device protocol.
Hear when a new Transplant-Related Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.