Comparing treatments for a failed TAVR valve
Part of Heart & circulation clinical trials.
This trial compares two ways to fix a previously placed TAVR heart valve that is no longer working well: surgically removing it (TAVR-explant) or placing a new TAVR valve inside it (redo-TAVR). It is for people who are having symptoms because their valve is failing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a heart valve that was replaced with a TAVR (a catheter-based procedure) but is now failing and causing symptoms.
- Your heart team must agree that both options — removing the old valve surgically or placing a new TAVR valve inside it — are possible for you.
- You need to be willing and able to come back for all follow-up appointments after the procedure.
- You must not have an active infection like sepsis or endocarditis.
- You must not have severe dementia that would prevent you from giving consent or following study rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study follows people who successfully had their first TAVI but later needed their replacement valve treated again with a “redo” TAVI. It’s mainly about tracking outcomes and safety over time to better understand who may benefit from a repeat TAVI.
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This trial tests a second transcatheter aortic valve replacement (TAVR) procedure for patients whose first TAVR valve is failing. It focuses on structural problems inside the valve, not leakage around it.
This trial is for people who have already had a TAVI (a minimally invasive aortic valve replacement) and now need a second procedure because the valve is failing. The study will test how well a redo TAVI works to fix the failing valve.
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
This trial is studying how well a new type of heart valve works in real-life patients with aortic valve disease. It will help doctors understand if this valve is safe and effective for people who need a procedure called TAVR (transcatheter aortic valve replacement).
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