Emapalumab for children with severe aplastic anemia
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests whether a medication called emapalumab can help children with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. It combines emapalumab with standard immune-suppressing therapy to try to improve blood cell counts.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are under 25 years old and have been diagnosed with severe aplastic anemia, meaning your bone marrow is very low in cells and you have low counts of at least two types of blood cells (such as neutrophils, platelets, or reticulocytes).
- You have not had any previous treatment for severe aplastic anemia.
- You do not have leukemia, myelodysplastic syndrome, or an inherited bone marrow failure condition.
- You are able to take the study medication and follow the treatment plan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a medication called romiplostim, which helps the body make more blood cells, for children and young adults with severe aplastic anemia. It may help improve blood counts and reduce the need for transfusions.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
This study tests a new antibody drug (anti-CD38) for people with severe aplastic anemia that has not responded to or has come back after standard treatments. The goal is to see if this drug can help improve blood counts when other options have failed.
This study is testing whether a stem cell transplant (from a matched relative, unrelated donor, or half-matched donor) can help adults aged 40–60 with severe aplastic anemia that didn't get better or came back after standard treatments.
This trial tests whether a new combination of medicines can help treat severe aplastic anemia (SAA) or a related type (TD-NSAA). It uses a drug that helps your body make more platelets, along with immunosuppressants, and may offer an alternative if a bone marrow transplant isn't possible.
This trial tests a combination of drugs to help your bone marrow make more blood cells if you have aplastic anemia and cannot have a stem cell transplant or standard immune therapy. It might improve blood counts and reduce the need for transfusions.
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