Comparing two medicines for fluid buildup in heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether adding acetazolamide or metolazone to standard treatment helps remove extra fluid better in people hospitalized for heart failure. It aims to find a safer and more effective option for managing fluid overload.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with acute decompensated heart failure (sudden worsening of heart failure symptoms).
- You have signs of fluid overload, such as swelling in the legs or belly, or fluid around the lungs.
- Your BNP or NT-proBNP levels are higher than normal at the start of the study.
- You have been taking at least 40 mg of furosemide (a water pill) by mouth for at least one month before joining.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding an oral water pill (acetazolamide) to standard IV furosemide helps people with acute heart failure who have fluid overload. It aims to see if the combination improves outcomes better than furosemide alone.
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
This study tests whether adding acetazolamide (a different type of water pill) to your current treatment helps remove extra fluid from your body more effectively when you are in the hospital for heart failure.
This trial compares two different water pills (acetazolamide and metolazone) added to standard treatment to help remove excess fluid in people hospitalized with acute heart failure. The goal is to find which works better to ease symptoms and improve recovery.
This trial tests a new use of the drug acetazolamide (commonly used for other conditions) to help remove extra fluid and reduce weight in people with heart failure. It might help relieve symptoms like swelling and shortness of breath.
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