Modified immune cells for HPV-related advanced cancers
Treatments studied
Part of Cancer, Digestive system, Ear, nose & throat, Kidney & urinary, Mouth & dental, Women’s health & pregnancy clinical trials.
This trial tests a new treatment using your own immune cells (called T cells) that are modified to target HPV-positive cancer cells. It may be an option if you have advanced cervical, head/neck, anal, penile, vulvar, or vaginal cancer that is HPV16 or HPV52 positive and has progressed after standard therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a type of cancer that started in the cervix, head/neck, anus, penis, vulva, or vagina.
- Your tumor must be positive for HPV type 16 or 52.
- You must have the HLA-A*02:01 gene type (a blood or tissue test will show this).
- Your cancer must have spread or come back after at least one standard treatment like chemo or immunotherapy.
- You must be well enough to be up and about (ECOG score 0 or 1) and have adequate organ function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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