Denosumab for Preserving Insulin in Type 1 Diabetes
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This study tests if denosumab, a drug normally used for bone health, can help preserve your body's own insulin production in type 1 diabetes. It might slow the loss of insulin-making cells, helping you maintain better blood sugar control over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 50 (female) or 21 and 50 (male) and have type 1 diabetes for at least 1 year but not more than 5 years.
- You still make some of your own insulin (C-peptide level of at least 0.2 nmol/L).
- You have had at least one positive antibody test for type 1 diabetes (GAD, IA-2, or ZnT8).
- Your hemoglobin A1c is 9.5% or lower, and you haven't had severe low blood sugar or DKA in the last 3 months.
- You are not taking any diabetes medications other than insulin, and you have not used certain bone-related drugs (like bisphosphonates) in the past year.
- You have not had a major bone fracture or jaw problems in the last year, and your vitamin D level is normal.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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