Radiation conditioning before sibling stem cell transplant for pediatric ALL
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This study tests two types of radiation-based conditioning (TBI or TMLI) before a stem cell transplant from a matched sibling donor, in children with ALL that is in remission. The goal is to see which approach works better and is safer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child must be between 1 and 17 years old and have acute lymphoblastic leukemia (ALL).
- The leukemia must be in complete remission (no signs of active disease) before the transplant.
- Your child must have a brother or sister who is a good match for donating stem cells (matched sibling donor).
- Your child must be in good overall health: able to care for themselves, with normal heart, liver, kidney, and lung function, and no active infections.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a stem cell transplant using a half-matched family donor for children with acute lymphoblastic leukemia (ALL) that is in remission. It compares two different types of radiation conditioning to prepare the body for the new cells, with the goal of improving outcomes.
This trial tests two different conditioning regimens (total body irradiation or total marrow/lymphoid irradiation) before a stem cell transplant from a matched sibling donor for adults with acute lymphoblastic leukemia (ALL) that is in remission. The goal is to see which regimen works better and has fewer side effects.
This trial studies a new way to prepare adults with ALL for a stem cell transplant from a half-matched family donor. It compares two types of radiation-based conditioning to see which works better and has fewer side effects.
This trial is studying better ways to manage stem cell transplants for children and young adults with acute lymphoblastic leukemia (ALL). It aims to improve outcomes by testing different approaches to transplant care.
This Phase 3 trial studies the best “conditioning” chemotherapy plan before an allogeneic stem cell transplant for children with AML. It may help improve outcomes by testing an approach for kids who are ready for transplant after relapse or specific high-risk features.
This study looks at whether some children and young adults with B-ALL can safely get a transplant without total body irradiation (TBI), based on special leukemia test results. It’s meant to help lower radiation-related risks while keeping leukemia control strong.
Hear when a new Acute Lymphoblastic Leukemia, Pediatric trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.