Dexmedetomidine for kidney protection in sepsis
Treatments studied
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests if dexmedetomidine, a sedative, can help protect the kidneys of critically ill patients with sepsis who develop acute kidney injury (a sudden drop in kidney function). It is for adults in the ICU who need a breathing tube or mask within 48 hours of kidney injury.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are older than 21 years
- You have sepsis (a severe infection that affects your whole body)
- You developed sudden kidney injury within 48 hours of being in the ICU
- You need a breathing tube or mask (mechanical ventilation) within 48 hours of that kidney injury
- You are not pregnant or breastfeeding
- You do not have a very slow heart rate, certain heart rhythm problems, very low blood pressure, recent heart attack, severe heart valve disease, active seizures, or brain/spinal cord injury
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an early use of a sedative medicine called dexmedetomidine in people with septic shock. It aims to calm the body's stress response, which might improve recovery.
This study tests whether adding a sedative called dexmedetomidine affects blood flow in tiny vessels under the tongue and overall circulation in patients with septic shock. It may help doctors choose better sedation to improve recovery.
This trial tests if a new drug, AZD4144, can help people with sepsis-related acute kidney injury in the ICU. It aims to see if the drug can improve kidney recovery and reduce complications.
This trial tests ways to protect the kidneys in intensive-care patients who have moderate or severe acute kidney injury. If you are on a ventilator or medications to support blood pressure, this study may offer extra kidney care to help prevent further damage.
This study tests two medicines given through an IV to treat delirium (confusion or agitation) in people who are in the intensive care unit with acute heart failure. The goal is to see which medicine works better to clear the confusion and improve recovery.
This trial studies a sedative drug called dexmedetomidine given during kidney transplant surgery to see if it helps protect the new kidney. It might help the kidney work better after the operation.
Hear when a new Sepsis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.