Comparing two IV sedatives for delirium in heart failure patients
Treatments studied
Part of Brain & nervous system, Heart & circulation, Mental health clinical trials.
This study compares two sedative medications, ketamine and dexmedetomidine, given through an IV to treat delirium (confusion) in patients with acute heart failure in the intensive care unit. The goal is to see which drug is more effective and safer for reducing delirium symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a confirmed diagnosis of acute heart failure.
- You must be in the ICU and have active delirium (confusion) that is not due to a primary brain issue.
- You must not have severe liver or kidney disease.
- You must not have taken antipsychotics, benzodiazepines, or other sedatives in the last 48 hours.
- You must not be pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests two different sedation medicine combinations to see which one reduces confusion and agitation (called delirium) when children with burn injuries need procedures done. The goal is to find the safest, most comfortable option for your child during treatment.
This trial tests if combining two medicines, esketamine and dexmedetomidine, is better than dexmedetomidine alone for calming severe confusion and agitation in ICU patients who need breathing support through a mask or nasal tubes. It aims to find a safer, more effective way to help patients rest and recover.
This trial tests two medicines, haloperidol and dexmedetomidine, to see which one works better for calming confusion and agitation in ICU patients who have a traumatic brain injury and are on a breathing machine. If you qualify, the study may help your doctors choose the best treatment for you.
This study tests a combination of two medicines, dexmedetomidine and esketamine, to help keep ICU patients calm and comfortable while on a breathing machine. The goal is to see if this combination works well for sedation and pain relief.
This trial tests whether a sedating medicine called dexmedetomidine can reduce the risk of “delirium” (sudden confusion) in the intensive care unit after open-heart surgery. If you’re having certain heart operations, it may help protect your thinking and alertness during recovery.
This trial tests whether a newer sedative (remimazolam) or a commonly used one (dexmedetomidine) is better at preventing delirium after planned heart surgery that requires a heart-lung machine. If you are having elective coronary bypass or valve surgery, you may be able to join.
Hear when a new Delirium in Intensive Care Unit trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.