Modified eye surgery for moderate to severe Graves' eye disease
Part of Eyes & vision, Genetic & congenital, Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests a modified orbital decompression surgery to treat moderate-to-severe swelling and bulging of the eyes caused by Graves' disease. It aims to improve eye function and appearance for people whose thyroid condition has been stable for at least 6 months.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have moderate-to-severe Graves' eye disease (your eyes bulge and cause discomfort).
- Your eye inflammation is currently low (CAS score of 3 or less).
- Your thyroid function has been stable for at least 6 months (on medication, post-surgery, or post-radioiodine).
- You don't have any major uncontrolled health problems (like severe heart or lung disease, or active cancer).
- You don't have other eye conditions that cause bulging (like tumors or fibromas) or other serious eye diseases (like glaucoma or diabetic retinopathy).
- You are willing to attend regular follow-up visits after surgery.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether teprotumumab (a monoclonal antibody medication) works better than high-dose steroids after urgent eye socket surgery in patients with thyroid eye disease affecting the optic nerve. The goal is to prevent vision loss and improve eye symptoms.
This study tests whether high-dose steroid pulses (given through a vein) can help people with moderate to severe Graves' eye disease that is still active. It is for people who have not yet been treated with steroids and whose eye problems began within the past year.
This trial studies whether hydroxychloroquine can improve mild Graves’ orbitopathy (swelling and discomfort around the eyes). It’s meant for people with mild symptoms and who haven’t recently used certain eye or immune treatments.
This study tests whether the cholesterol-lowering drug atorvastatin can help people with active, moderate-to-severe thyroid eye disease (swelling and bulging of the eyes caused by an overactive thyroid). You will receive the drug or a placebo alongside your usual steroid treatment, and your eyes will be checked over about a year.
This trial tests whether simvastatin (a cholesterol medicine) can improve eye symptoms from Graves’ eye disease. It is aimed at people with active mild-to-moderate disease and will also check safety with blood tests, heart/skin tolerance, and stomach health.
This trial tests two different ways of giving a steroid medicine (methylprednisolone) through an IV to treat active Graves' eye disease. The goal is to see which approach works better and is safer for people with moderate to severe symptoms.
Hear when a new Graves Ophthalmopathy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.