Deep brain stimulation for depression that hasn't responded to other treatments
Part of Mental health clinical trials.
This trial tests if deep brain stimulation (a surgical implant that sends gentle electrical pulses to a specific area of the brain) can help people with bipolar I disorder who are currently in a severe depressive episode and have not found relief from multiple treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 22 and 64 years old.
- You must have a diagnosis of bipolar I disorder and be in a major depressive episode.
- You must have tried at least four different treatments for bipolar depression, including two FDA-approved medications or ECT, and they didn't work well enough or the effect didn't last.
- You must be taking at least one stable medication for bipolar disorder (unless none are tolerated) for at least four weeks before surgery.
- You must be able to have an MRI and have no other implanted stimulation devices, like a pacemaker.
- You must not be pregnant or planning to become pregnant in the next two years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
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