Antibiotics before surgery for oral cancer
Treatments studied
Part of Cancer, Mouth & dental clinical trials.
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with oral cancer (squamous cell carcinoma of the mouth).
- You are scheduled for surgery to remove the cancer with the goal of curing it.
- You are 18 years old or older.
- You are willing and able to sign a consent form to participate.
- You are not allergic to metronidazole or chlorhexidine (the study drugs).
- You do not have severe liver or kidney disease.
- You can stop drinking alcohol for the 10 days you take the antibiotics.
- You have not had radiation or chemoradiation for a previous oral cancer.
- Your cancer can be removed by surgery (it is not unresectable).
- You can take the antibiotic by mouth or through a feeding tube and can tolerate the mouth rinse.
- You have not taken any other antibiotics in the last 30 days.
- You are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study compares doing surgery alone versus giving a combination of focused radiation (SBRT) and chemotherapy with an immunotherapy drug before surgery for mouth or throat cancer. The goal is to see if the pre-surgery treatment makes the cancer shrink more and improves outcomes.
This trial tests giving anti–PD-1 immunotherapy plus a drug called TP before surgery for oral squamous cell carcinoma (mouth/throat cancer). The goal is to see whether this pre-surgery treatment improves how much the tumor responds under the microscope.
This Phase 2 study tests medicines given before surgery for stage III/IV oral squamous cell carcinoma, choosing the treatment based on your tumor marker results. It aims to shrink the cancer and improve outcomes by using two targeted types of therapy.
This Phase 2 study tests whether taking metronidazole, an antibiotic, before surgery for colorectal cancer can improve outcomes. Participants take it before their planned operation, and doctors study the cancer tissue and related markers to see if it helps.
This trial tests if taking antibiotics before standard treatment can improve outcomes for people with advanced rectal cancer that requires surgery.
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