Antibiotics before surgery for oral cancer
Treatments studied
Part of Cancer, Mouth & dental clinical trials.
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with oral cancer (squamous cell carcinoma of the mouth).
- You are scheduled for surgery to remove the cancer with the goal of curing it.
- You are 18 years old or older.
- You are willing and able to sign a consent form to participate.
- You are not allergic to metronidazole or chlorhexidine (the study drugs).
- You do not have severe liver or kidney disease.
- You can stop drinking alcohol for the 10 days you take the antibiotics.
- You have not had radiation or chemoradiation for a previous oral cancer.
- Your cancer can be removed by surgery (it is not unresectable).
- You can take the antibiotic by mouth or through a feeding tube and can tolerate the mouth rinse.
- You have not taken any other antibiotics in the last 30 days.
- You are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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