Cd7 car-t before stem cell transplant for severe aplastic anemia
Treatments studied
Part of Blood & lymphatic clinical trials.
This trial tests a new approach: first, you receive a specially engineered immune cell treatment (CD7 CAR-T) to help prepare your body, then a stem cell transplant from a relative. It's designed for people with severe aplastic anemia who cannot have or choose not to get a standard transplant.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aplastic anemia, meaning your bone marrow makes very few blood cells and you have low counts of white cells, platelets, or red blood cells.
- You have a related donor (like a sibling or parent) who can give stem cells, at least a half-match.
- You are not able or choose not to have a standard stem cell transplant.
- Your kidneys, liver, heart, and lungs are working well enough (doctors will check these with tests).
- You are well enough to carry out daily activities (ECOG score 0 or 1).
- You agree to use birth control if you or your partner can become pregnant, for 6 months after the treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is testing whether a stem cell transplant (from a matched relative, unrelated donor, or half-matched donor) can help adults aged 40–60 with severe aplastic anemia that didn't get better or came back after standard treatments.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
This trial tests a new treatment called CD7 car-t cells (rd13-02) for people with severe aplastic anemia that has not responded to standard therapy or has come back. The goal is to see if this therapy can help restore normal blood cell production.
This trial tests a new way to prepare the body for a donor stem cell transplant (allogeneic transplant) in people with severe aplastic anemia or other blood diseases. The goal is to make the transplant safer and more effective.
This trial tests a new way of using a mix of donor stem cells (from a half-matched family member and a cord blood unit) to treat aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if this transplant approach is safe and helps rebuild healthy blood cells.
This trial tests a new approach for people with non-cancerous blood and immune system diseases. It uses your own engineered immune cells (CAR-T cells) to prepare your body for a stem cell transplant from a relative.
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