Cord blood stem cell transplant for aplastic anemia
Part of Blood & lymphatic clinical trials.
This study tests whether adding umbilical cord blood to a stem cell transplant from a half-matched donor can improve outcomes for people with severe aplastic anemia or related bone marrow failure diseases.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 75 years old.
- You have been diagnosed with severe aplastic anemia, transfusion-dependent non-severe aplastic anemia, or paroxysmal nocturnal hemoglobinuria (PNH) with bone marrow failure.
- Your doctor has said a stem cell transplant is a suitable treatment for you.
- You or your legal guardian understand the study and agree to join by signing a consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new way of using a mix of donor stem cells (from a half-matched family member and a cord blood unit) to treat aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if this transplant approach is safe and helps rebuild healthy blood cells.
This trial tests a new way to treat severe aplastic anemia by combining a stem cell transplant from a half-matched donor with special stem cells from umbilical cord blood. The goal is to help your body make healthy blood cells again.
This study tests a special cord blood transplant that may help your body start making blood cells faster than a regular transplant. It is for people with severe aplastic anemia or related bone marrow failure who have not gotten better with other treatments.
This trial studies using a donor's blood stem cells (from bone marrow or blood) for a transplant in people with severe aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if using a mix of both types of cells is better than just blood cells alone.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
This trial tests a new way of preparing adult patients with hard-to-treat aplastic anemia for a stem cell transplant. It uses a lower-intensity conditioning regimen (TMI) and umbilical cord blood, which may be safer and more effective for patients who have failed other treatments.
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