Treatment for MDS/MPN Overlap Syndrome
Part of Blood & lymphatic, Cancer clinical trials.
This study tests a combination of two drugs (azacitidine or ruxolitinib plus selinexor) for people with MDS/MPN overlap syndrome, a type of blood cancer. It aims to see if this treatment helps control symptoms and improve blood counts.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a diagnosis of MDS/MPN overlap syndrome (a specific blood cancer) that needs treatment because of symptoms like low blood counts, an enlarged spleen, or feeling very tired.
- You must have good liver and kidney function, and be able to walk and care for yourself (ECOG score 0-2).
- You cannot have had your spleen removed, or have active infections, serious heart problems, or other active cancers.
- You must not have evidence of acute leukemia (more than 20% blast cells in your bone marrow or blood).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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