Milrinone to prevent heart problems after PDA closure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests if giving milrinone before surgery to close a common heart vessel (PDA) can prevent heart issues in premature babies. It may help very premature infants who need surgery for a large PDA.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Born at 27 weeks or less and less than 3 months old at time of treatment
- On breathing support like a ventilator or CPAP (not just low-flow oxygen)
- Has a large PDA (at least 1 mm wide) found in the last 2 days
- Your baby's care team has decided to close the PDA with surgery or a catheter procedure
- No major birth defects, no serious heart defects (except small holes), no recent kidney failure, no blood pressure medicines, and no history of abnormal heart rhythm
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares an early procedure to close a heart vessel called the ductus arteriosus versus careful observation alone in very low-birth-weight preterm infants. It aims to see whether closing the vessel early can improve outcomes and be done safely.
This trial tests whether giving milrinone through a vein and inhaled during mitral valve surgery helps people with severe pulmonary hypertension. The goal is to improve heart and lung blood-flow stability around the time of surgery.
This trial tests a personalized approach for treating a heart duct problem (PDA) in very premature babies (born before 32 weeks). It uses special markers and drug delivery systems to find the best treatment for each baby.
This trial studies whether giving medicine soon can help preterm babies with a patent ductus arteriosus (a temporary leaking blood vessel in the heart). It aims to see if early treatment improves outcomes for very early gestational age infants.
This Phase 2 trial tests whether inhaled medicines (milrinone and epoprostenol) can make it easier to separate from the heart-lung machine during cardiac surgery. It may help reduce the risk of a difficult transition off the machine for the right patients.
This early study looks at how well the heart is pumping in people with cardiogenic shock, using measurements taken during a right-heart catheter (a small pressure-monitoring test). It may help doctors better assess heart function and guide next-step treatments like LVAD, heart transplant, or valve surgery.
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