Milrinone to prevent heart problems after PDA closure
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests if giving milrinone before surgery to close a common heart vessel (PDA) can prevent heart issues in premature babies. It may help very premature infants who need surgery for a large PDA.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Born at 27 weeks or less and less than 3 months old at time of treatment
- On breathing support like a ventilator or CPAP (not just low-flow oxygen)
- Has a large PDA (at least 1 mm wide) found in the last 2 days
- Your baby's care team has decided to close the PDA with surgery or a catheter procedure
- No major birth defects, no serious heart defects (except small holes), no recent kidney failure, no blood pressure medicines, and no history of abnormal heart rhythm
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares an early procedure to close a heart vessel called the ductus arteriosus versus careful observation alone in very low-birth-weight preterm infants. It aims to see whether closing the vessel early can improve outcomes and be done safely.
This trial tests whether giving milrinone through a vein and inhaled during mitral valve surgery helps people with severe pulmonary hypertension. The goal is to improve heart and lung blood-flow stability around the time of surgery.
This study tests a personalized approach to treating a common heart condition in very early preterm babies, where a blood vessel (the ductus arteriosus) stays open. It aims to find the best time and way to close this vessel using medication, based on the baby's specific biomarkers.
This trial creates a registry to gather information on premature babies who have a PDA (an open blood vessel in the heart) and are getting it closed with a catheter-based device. It helps doctors learn more about how safe and effective this treatment is for these tiny babies.
This trial tests a procedure that closes a small heart tube (called the ductus arteriosus) that stays open after birth. The goal is to see if closing it helps the heart work better in teens and adults.
This Phase 2 trial tests whether inhaled medicines (milrinone and epoprostenol) can make it easier to separate from the heart-lung machine during cardiac surgery. It may help reduce the risk of a difficult transition off the machine for the right patients.
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