Milrinone during heart surgery for severe pulmonary hypertension
Treatments studied
Part of Heart & circulation, Lungs & breathing clinical trials.
This trial tests whether giving milrinone through a vein and inhaled during mitral valve surgery helps people with severe pulmonary hypertension. The goal is to improve heart and lung blood-flow stability around the time of surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for mitral valve surgery that uses a heart-lung machine (cardiopulmonary bypass).
- Your pre-surgery ultrasound suggests severe pulmonary hypertension (estimated mean lung artery pressure 55 or higher).
- Surgery must not be an emergency or a repeat surgery (re-do).
- Your heart’s pumping strength should not be severely reduced (left ejection fraction must be 30% or higher).
- You should not have kidney or liver disease severe enough to rule you out.
- You should not have bleeding/clotting problems or blood clot disease that is being treated with blood thinners.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two medicines, milrinone and epinephrine, given during heart surgery to see which one better helps the right side of the heart work. It may help patients with weaker right heart function.
This Phase 2 trial tests whether inhaled medicines (milrinone and epoprostenol) can make it easier to separate from the heart-lung machine during cardiac surgery. It may help reduce the risk of a difficult transition off the machine for the right patients.
This trial tests if giving milrinone before surgery to close a common heart vessel (PDA) can prevent heart issues in premature babies. It may help very premature infants who need surgery for a large PDA.
This early study looks at how well the heart is pumping in people with cardiogenic shock, using measurements taken during a right-heart catheter (a small pressure-monitoring test). It may help doctors better assess heart function and guide next-step treatments like LVAD, heart transplant, or valve surgery.
This study tests whether using a special monitor in the heart (pulmonary artery catheter) during surgery helps doctors care for patients better. It is for adults having heart or major chest surgery, but does not include very high-risk emergency cases.
This trial tests a short-acting beta-blocker called Landiolol given during mitral valve surgery to see if it helps the heart recover after surgery. It is for patients who have certain signs of heart strain before their operation.
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