Combination drugs for lung cancer that has spread to the brain
Treatments studied
Part of Brain & nervous system, Cancer, Lungs & breathing clinical trials.
This trial tests a new combination of two drugs (utidelone and bevacizumab) for people with advanced non-small cell lung cancer that has spread to the brain. The goal is to see if this combination can control the brain tumors and slow down the disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your lung cancer must be a non-squamous kind (usually adenocarcinoma) that has spread to the brain, but you are not able or willing to have surgery or radiation for the brain spots right now.
- Your brain metastases must be stable and not causing serious symptoms or needing immediate treatment.
- You must have already had first-line treatment with platinum-based chemotherapy and immunotherapy, and it either stopped working or you couldn't tolerate it.
- You cannot have certain gene changes (like EGFR, ALK, ROS1, NTRK, or MET) that would be treated with targeted pills instead.
- You need to be in good physical shape (ECOG 0-1) and have enough bone marrow, liver, and kidney function, with no recent bleeding or clotting problems.
- You must not have had serious bleeding in the brain, uncontrolled high blood pressure, or major surgery in the last few weeks, and you must be willing to use contraception if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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