Clin2
NCT06686108Possibly a fitRecruiting

Medication combo to prevent lymphoma relapse after transplant

T-cell Acute Lymphoblastic LeukemiaALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATIONRelapse

Treatments studied

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This trial tests a combination of two drugs (a demethylating agent and venetoclax) to help prevent high-risk T-cell lymphoma or leukemia from coming back after a stem cell transplant. It is for patients who have certain risk factors for relapse.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
59 people
Ages
14 years to 55 years
Study type
Interventional

Who can take part

  • You are between 14 and 55 years old.
  • You have had a stem cell transplant for T-cell lymphoma or leukemia.
  • You have at least one high-risk factor for relapse (such as high white blood cell count at diagnosis, a large tumor in the chest, or certain gene changes).
  • You are currently in remission or have stable blood counts (ANC >= 1.0 and platelets >= 50).
  • You do not have active graft-versus-host disease (GVHD) or severe organ problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06754540Not yet recruiting· Phase 2
Preventing leukemia relapse after transplant with azacitidine and donor cells

This study tests whether giving a drug called azacitidine along with donor lymphocyte infusions (white blood cells from your original donor) can help prevent leukemia from coming back after a stem cell transplant. If you are at high risk for relapse, this combination might lower that risk.

NCT07513129Recruiting· Phase 1
New drug combination for relapsed T-cell blood cancer in teens and young adults

This trial tests a combination of four drugs (venetoclax, dexamethasone, bortezomib, and daratumumab) to treat T-cell acute lymphoblastic leukemia or lymphoma that has come back or stopped responding to prior treatment. The goal is to see if this combination can help patients aged 12–30 achieve remission.

Houston, Texas
NCT07389616Recruiting· Phase 2/Phase 3
Preventing lymphoma return after transplant

This trial tests a combination of two drugs (cidabenamine and azacitidine) to help prevent peripheral T-cell lymphoma from coming back after a donor stem cell transplant. It is for patients who are at high risk of progression and have already had a transplant.

Shanghai, Shanghai Municipality
NCT07635485Not yet recruiting
Venetoclax and azacitidine before a stem cell transplant for AML

This trial studies a combination of two medicines (venetoclax and azacitidine) as a bridge to a stem cell transplant for people with a hard-to-treat type of AML (like secondary AML or with low bone marrow cells). The goal is to get the leukemia under control so a transplant can be done successfully.

Suzhou, Jiangsu
NCT06483906Recruiting· Phase 2
Study of a drug combo and stem cell transplant for high-risk AML

This trial tests a combination of three drugs (venetoclax, azacitidine, and homoharringtonine) followed by a donor stem cell transplant for people with intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if this approach can improve outcomes for patients who have not been treated before.

Shanghai, Shanghai Municipality
NCT05404906Recruiting· Phase 2/Phase 3
Azacytidine plus venetoclax to prevent AML coming back

This trial studies azacytidine (AZA) plus venetoclax as maintenance treatment to help keep acute myeloid leukemia (AML) in first remission. It may help delay or prevent AML from returning in younger adults who cannot get a stem cell transplant right away.

Suzhou, Jiangsu

Hear when a new T-cell Acute Lymphoblastic Leukemia trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.