C. difficile infection study in healthy volunteers
Treatments studied
Part of Infections clinical trials.
This trial studies how Clostridioides difficile (C. diff) affects healthy people by intentionally giving a controlled dose. The goal is to understand the infection better and help develop future treatments or vaccines.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 45 years old and in good health
- Your body mass index (BMI) is between 18 and 30
- You can understand the study requirements and follow hygiene instructions
- If you could become pregnant, you must use effective birth control and not breastfeed
- You have not taken antibiotics in the last 3 months or other drugs affecting gut bacteria in the last month
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at levels of C. diff toxins in stool after standard antibiotic treatment. It aims to understand how toxins change during recovery, which may help improve future treatments for C. diff infections.
This trial tests a treatment called washed microbiota transplantation (WMT) for people with a C. diff infection that causes diarrhea. WMT uses processed donor bacteria to help restore healthy gut balance and fight the infection.
This study is tracking patients with a confirmed C. difficile infection to understand how the body responds and how treatments work. You may be asked to do follow-up visits for up to 5 years.
This Phase 1 study tests defined fecal microbiota (healthy gut bacteria) given to people with C. difficile diarrhea that didn’t go away or came back soon after antibiotics. It may help by restoring a healthier balance of gut bacteria so the infection can stop recurring.
This trial studies using a fecal microbiota transplant (FMT)—healthy gut bacteria moved from a screened donor—to help treat recurring or hard-to-control C. difficile infection. It may help restore a healthier gut environment when standard treatments keep failing or the infection returns.
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