Comparing two treatments for worsening stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether adding carbon dioxide (CO2) to a medicine called phenylephrine helps people whose stroke is getting worse. It compares this combination to using phenylephrine alone, with the goal of improving recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 20 years of age or older.
- You had a stroke in the front part of the brain that is getting worse.
- Your stroke symptoms have worsened by at least 1 point on the NIHSS scale or your muscle strength has decreased by 1 grade on the MRC scale.
- You do not have conditions that increase risk of brain swelling, Moyamoya disease, or severe blood vessel problems in the brain.
- You are able to undergo CO2 treatment (no panic disorder, anxiety disorder, or other psychiatric conditions).
- You are not allergic to phenylephrine and do not have very slow heart rate (under 50 beats per minute).
- You have not had a bleeding stroke and are not at high risk of bleeding in the brain.
- You were independent before your stroke (score of 0 or 1 on the modified Rankin Scale).
- You do not have recent heart attack or unstable chest pain in the past 3 months, heart failure with low ejection fraction (under 25%), irregular heart rhythm, very high blood pressure (over 200 mmHg), poor kidney function (creatinine over 2 mg/dL), or are not pregnant.
- You are not taking MAO inhibitors (a type of antidepressant).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether carefully lowering blood pressure after a mechanical clot removal procedure for stroke can improve outcomes. If you've had a large vessel stroke that was successfully treated with thrombectomy, this study will help guide blood pressure management in the recovery period.
This trial tests whether giving a combination of two medicines (chlorpromazine and promethazine) to put the body into a 'hibernation-like' state can help people having a severe stroke. You will also receive standard clot-removal treatment, and the study hopes to see if this approach improves recovery.
This study tests a combination of gentle brain-protecting treatments (temperature, oxygen, positioning, and nerve stimulation) given alongside standard clot-busting therapy for recent strokes. The goal is to see if the combination can help improve recovery and reduce disability after a stroke.
This trial tests a new approach to restore blood flow in the brain after a stroke. It aims to improve recovery and brain function in people with a blocked large artery.
This trial tests if a hibernation-like therapy can improve recovery after a stroke caused by a large blood clot in the brain. It is for people who are having a stroke and are scheduled for a procedure to remove the clot.
This trial tests whether a combination of two or three anti-platelet medicines (like aspirin, clopidogrel, or cilostazol) is safe and works better than one alone for people who had a stroke from a narrowed artery. The goal is to prevent another stroke.
Hear when a new Acute Ischemic Stroke trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.