Metyrapone for heart risk in adrenal tumors with Cushing's
Part of Hormones & metabolism clinical trials.
This trial tests if a drug called Metyrapone can lower heart risks in people who have adrenal nodules (noncancerous growths on the adrenal glands) and a mild form of Cushing's syndrome that doesn't cause obvious physical signs. You'll be given the drug and monitored to see if it helps control blood pressure and other heart risk factors.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have one or more adrenal nodules on a CT scan with thickening of the adrenal glands.
- You have a mild form of Cushing's syndrome (confirmed by specific hormone tests) without visible signs like weight gain or bruising.
- You have high blood pressure (140/90 or higher) or take medication for it.
- You cannot have surgery to remove the nodules.
- Your blood pressure is between 110/70 and under 130/85 after 6-10 months on a stable dose of blood pressure medication.
- You are not pregnant, not breastfeeding, and if you could become pregnant, you use double barrier contraception (like condom plus diaphragm).
- You have not used steroid medications in the last year.
- You do not have serious liver problems, untreated thyroid issues, or other conditions that would interfere with the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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