Comparing two drugs for metabolic autonomous cortisol secretion
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial tests whether metyrapone or osilodrostat works better for people with MACS, a condition where the adrenal glands produce too much cortisol on their own. The goal is to help you and your doctor choose the best treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 years old
- You have been diagnosed with metabolic autonomous cortisol secretion (MACS), shown by scans of your adrenal glands
- Your morning cortisol level after a low-dose dexamethasone test is above 1.8 mcg/dL, plus one of these: low ACTH, unusual bedtime saliva cortisol, or high urine cortisol in 24 hours
- You do not have any active or past cancer (including adrenal cancer)
- Your liver and kidney function are within safe limits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests if a medication called metyrapone can help people with mild autonomous cortisol secretion (MACS), a condition where your body makes too much cortisol. It looks at whether the drug improves related health problems like high blood pressure, diabetes, or bone issues.
This study tests whether a drug called Isturisa (osilodrostat) can safely lower mild cortisol excess in people with adrenal tumors. It aims to help patients avoid the long-term effects of too much cortisol.
This study looks for a mild form of hormone overproduction (called autonomous cortisol secretion) in people who have a benign growth on their adrenal gland. You will undergo a blood test to measure how well your body suppresses cortisol after taking a single dose of dexamethasone.
This study tests whether removing a small adrenal tumor or taking a diabetes/weight-loss medication (semaglutide) works better to improve health in people with mild hormone problems. It may help if you have an adrenal nodule causing slight cortisol overproduction or if you have obesity and related conditions.
This trial tests if tirzepatide can help with weight and blood pressure after you have surgery to remove an adrenal gland that's making too much cortisol. It may be a good option if you still have health issues like high blood pressure or obesity after surgery.
This study tests whether a low dose of the drug osilodrostat can help people with mild cortisol excess (MACS) caused by benign adrenal tumors. It may improve related health problems like high blood pressure, diabetes, or bone thinning.
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