Osilodrostat for high blood pressure in Cushing's syndrome
Treatments studied
Part of Cancer, Heart & circulation, Hormones & metabolism clinical trials.
This study tests a drug called osilodrostat (a pill) to see if it can lower blood pressure in people with Cushing's syndrome. If you have Cushing's and your blood pressure is still high despite medication, this trial might help you find better control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be at least 18 years old
- You must have a confirmed diagnosis of Cushing's syndrome
- Your blood pressure must be higher than normal (average 135/85 or more) despite taking blood pressure medications
- You must not have taken certain Cushing's treatments recently (varies by drug, from 1 week to 3 months)
- You must be able to take oral medication and follow the study requirements
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests how osilodrostat works in children and teens with Cushing’s syndrome—what the drug does in the body, how it affects hormones, and how safely it’s tolerated. It may help families who cannot have immediate surgery or whose surgery has already failed or is still pending.
This study looks at how Cushing’s syndrome affects people before treatment and what changes after treatment. It may help researchers understand what to expect and improve care for adults with newly diagnosed Cushing’s syndrome.
This trial tests if a drug called Metyrapone can lower heart risks in people who have adrenal nodules (noncancerous growths on the adrenal glands) and a mild form of Cushing's syndrome that doesn't cause obvious physical signs. You'll be given the drug and monitored to see if it helps control blood pressure and other heart risk factors.
This trial looks at how a natural hormone called aldosterone (which helps control blood pressure) and a treatment that silences it affect people with high blood pressure. It aims to find better ways to manage high blood pressure by studying real patient data.
This trial tests if iloperidone can lower blood pressure in people whose high blood pressure is not controlled by current medications. You may qualify if your blood pressure is still high after weeks of treatment.
This is a study that collects and reviews information about how people with Cushing’s syndrome (including some mild forms and certain “silent” tumors) are diagnosed and treated, and what outcomes they have. It may help researchers understand which treatments work best in different types of the condition.
Hear when a new High blood pressure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.