Clinical trials
Cushing Syndrome clinical trials
Below are recruiting cushing syndrome clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05804669RecruitingPhase 1/Phase 2
CRN04894 for active Cushing’s syndrome—safety and drug levels
This early-phase study tests how safe CRN04894 is and what drug levels it reaches in the body in people with “active” ACTH-dependent Cushing’s syndrome. You may be considered if your condition is currently active (or became active very recently) and you meet specific medication and imaging rules.
Bethesda, MarylandAges 18 years+ - NCT06635629RecruitingPhase 2
Desmopressin test for ACTH-dependent Cushing syndrome
This trial studies how well a desmopressin stimulation test works to diagnose ACTH-dependent Cushing syndrome. It compares results from people with possible or recurrent Cushing syndrome and healthy volunteers.
Bethesda, MarylandAges 18–70 - NCT03364803Recruiting
Sharing treatment results for people with Cushing’s syndrome
This is a study that collects and reviews information about how people with Cushing’s syndrome (including some mild forms and certain “silent” tumors) are diagnosed and treated, and what outcomes they have. It may help researchers understand which treatments work best in different types of the condition.
Basking Ridge, New JerseyAges 14 years+ - NCT03708900RecruitingPhase 2
Osilodrostat study for children with Cushing’s syndrome
This Phase 2 study tests how osilodrostat works in children and teens with Cushing’s syndrome—what the drug does in the body, how it affects hormones, and how safely it’s tolerated. It may help families who cannot have immediate surgery or whose surgery has already failed or is still pending.
San Francisco, CaliforniaAges 2–17 - NCT07350707RecruitingPhase 1/Phase 2
PET scan for Cushing's syndrome using two tracers
This trial tests if a special PET scan using two different tracers (68Ga-Pentixafor and 68Ga-DOTATATE) can help diagnose Cushing's syndrome and find its cause. It may help doctors better understand your condition and guide treatment.
Beijing, Beijing MunicipalityAges 10–80 - NCT02019706RecruitingPhase 2
PET/CT scans to find the cause of ectopic Cushing syndrome
This trial tests several special imaging scans to help doctors locate the source of hormone overproduction in ectopic Cushing syndrome. It may help confirm where the problem is so treatment can be better targeted.
Bethesda, MarylandAges 18–80 - NCT06801249RecruitingPhase 4
Metyrapone for heart risk in adrenal tumors with Cushing's
This trial tests if a drug called Metyrapone can lower heart risks in people who have adrenal nodules (noncancerous growths on the adrenal glands) and a mild form of Cushing's syndrome that doesn't cause obvious physical signs. You'll be given the drug and monitored to see if it helps control blood pressure and other heart risk factors.
BolognaAges 18–75 - NCT04543253Recruiting
Recovery study after Cushing surgery for cortisol excess
This study looks at how people recover after surgery to treat Cushing syndrome and mild cortisol overproduction. It may help doctors understand what recovery looks like and how treatment affects cortisol levels and symptoms.
Rochester, MinnesotaAges 18 years+ - NCT05521529Recruiting
Study of Cushing’s symptoms before and after treatment
This study looks at how Cushing’s syndrome affects people before treatment and what changes after treatment. It may help researchers understand what to expect and improve care for adults with newly diagnosed Cushing’s syndrome.
Aarhus, StateAges 18 years+ - NCT05881005Recruiting
NAC for fatty liver in people with active Cushing’s
This study tests whether NAC (a supplement/medicine) can improve liver health in adults who have active Cushing’s syndrome and fatty liver disease. It may help if your excess stress hormone levels are affecting your liver.
AngersAges 18 years+ - NCT05911620Recruiting
MRI test to measure liver scar severity in Cushing’s
This study uses a special MRI scan to measure how severe liver scarring is. It focuses on people with Cushing’s syndrome or suspected Cushing’s, or those with metabolic syndrome, to see how well the scan helps diagnose and assess severity.
NancyAges 18 years+ - NCT06573723Recruiting
Rare disease registry at Hospital Italiano
This study collects information from patients with certain rare diseases to better understand them. If you have one of these conditions and receive care at Hospital Italiano de Buenos Aires, you may be able to join.
Buenos Aires, Buenos AiresAges Any age - NCT00669266Recruiting
Study of adrenal tumors—causes and possible treatments
This study looks at adrenal tumors found on imaging (scans) to better understand what causes them and how they might be treated. If you have an adrenal tumor on a scan, this trial may be looking to enroll you for that purpose.
WürzburgAges Up to 100 years - NCT07703683Recruiting
Muscle health in metabolic and hormone diseases
This trial looks at how muscle health is affected by metabolic or hormone disorders, aiming to find better markers for muscle loss called sarcopenia.
Woluwe-Saint-Pierre - Sint-Pieters-WoluweAges 18 years+ - NCT06050057Recruiting
Surgery for adrenal disease: Standard vs. robotic-assisted approach
This study compares two types of minimally invasive surgery for removing an adrenal gland: laparoscopic (small incisions, using a camera) and robot-assisted (using a robotic arm). It aims to see which approach may be better for recovery and safety.
OlomoucAges 18 years+ - NCT06250699Recruiting
Rapid recovery after urologic surgery
This trial tests a program to help patients recover faster after urologic surgery. It focuses on making sure you heal well and get back to your normal life quickly.
Wuhan, HubeiAges 18–70 - NCT06430528Recruiting
Osilodrostat and steroid replacement for Cushing syndrome
This trial tests a new approach, called 'block-and-replace', for treating Cushing syndrome. You will take osilodrostat to lower high cortisol levels, along with a glucocorticoid (a steroid) to replace what your body needs. This study may help control the disease if surgery hasn't worked or isn't an option.
Ann Arbor, MichiganAges 18–75 - NCT06962202Recruiting
Modified Desmopressin PET/CT for Cushing's Syndrome
This trial tests a new way to use a medicine called desmopressin with a special type of imaging (PET/CT) to help find cortisol-producing tumors in people with Cushing's syndrome. It may help doctors better locate the problem without needing as much radiation.
ChandigarhAges 5–75 - NCT07168122Recruiting
Salivary cortisol test for adrenal health
This study is building a reference range for a simple saliva test that measures cortisol, a hormone linked to stress and adrenal function. It may help diagnose conditions like Cushing's syndrome or adrenal insufficiency.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT03474237Enrolling by invitation
Study following people newly diagnosed with adrenal conditions
This study follows adults with a new adrenal diagnosis to learn how adrenal diseases behave over time. It may help doctors better understand these conditions and improve future care.
SeoulAges 19 years+ - NCT06246357RecruitingPhase 2
Testing adrenal gland function with a special scan
This trial uses a special PET scan (68Ga-PentixaFor) to check how well your adrenal glands are working if you have high aldosterone or cortisol levels. It helps doctors see if the glands are making too much hormone, which may guide treatment.
Bethesda, MarylandAges 18–120 - NCT07182175Enrolling by invitation
Heart health during adrenal tumor surgery study
This study looks at how different types of adrenal tumors might affect the heart during and after surgery. It aims to help doctors understand and reduce the risk of heart injury in patients having these tumors removed.
BeijingAges 18 years+
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Cushing Syndrome trials by city
Studies with a site in or near these metro areas.
Cushing Syndrome trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cushing syndrome?
- Yes. Clin2 currently lists 22 recruiting cushing syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cushing syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cushing syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.