Vortioxetine for depression and freezing of gait in Parkinson disease
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether the antidepressant vortioxetine can reduce both depressive symptoms and freezing of gait (when your feet feel stuck) in people with Parkinson's disease. If you qualify, you may receive the medication to see if it helps these challenging symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Parkinson's disease.
- You feel depressed, confirmed by a questionnaire score of 15 or higher.
- You have moderate to severe freezing of gait (feet feel stuck) that does not get better with your usual Parkinson's medications.
- You are not taking other antidepressants or certain MAO-B Parkinson's drugs (or you can stop them for 15 days).
- You do not have serious liver or kidney problems, tramadol or triptan use, psychotic disorder, or dementia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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