Comparing two mitral valve replacement techniques for rheumatic heart disease
Part of Heart & circulation clinical trials.
This trial compares two surgical techniques for replacing the mitral valve. One technique keeps more of the natural supporting structures (the subvalvular apparatus) than the other. The goal is to find out which approach gives better heart function and quality of life after surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 60 years old.
- Your mitral valve problem is caused by rheumatic heart disease (from a past strep infection).
- You also have another heart valve problem besides the mitral valve.
- You have not had heart surgery before.
- Your mitral valve problem is not caused by blocked heart arteries (ischemic).
- Your surgery is not an emergency, and you do not have severe lung disease or end-stage kidney disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is testing a replacement valve (called MITRIS) for people whose own mitral valve or a previous artificial valve is not working well. The goal is to see how well the valve works over time after it is implanted.
This early-stage trial tests a new device called the ReValve System that replaces a damaged mitral valve (the valve that controls blood flow in your heart). The study is for people with a weakened heart who have leaking mitral valves and are experiencing heart failure symptoms.
This trial tests a new device that replaces a damaged mitral heart valve without open-heart surgery. It aims to help people whose leaky valve causes symptoms like shortness of breath or fatigue, and who cannot have standard treatments.
This trial compares doing mitral valve repair early versus closely monitoring without surgery in people who have severe leakage but no symptoms. It aims to see whether early repair helps prevent future heart problems.
This trial tests a new device to fix a leaky mitral valve in people with moderate to severe leakage who are too high-risk for open-heart surgery. It aims to improve heart function and symptoms.
This study is for people with severe mitral valve leakage (mitral regurgitation) who may need a valve replacement. It tests whether the ReValve system is safe and can help improve symptoms and heart function.
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