Preventing GVHD after stem cell transplant for leukemia
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests adding ruxolitinib to standard drugs (tacrolimus and methotrexate) to prevent graft-versus-host disease in children and young adults undergoing a stem cell transplant for acute leukemia or myelodysplastic syndrome. The goal is to lower the risk of GVHD and improve transplant outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 2 and 22 years old
- You weigh at least 25 kilograms (about 55 pounds)
- You have acute myeloid leukemia, acute lymphoblastic leukemia in remission, or myelodysplastic syndrome
- You have a matched related or unrelated donor willing to give bone marrow or stem cells
- You are not pregnant or breastfeeding, and agree to use birth control for 6 months after treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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