Clin2
NCT06837948Possibly a fitNot yet recruiting

Neoadjuvant chemotherapy with bispecific antibody for lung cancer

Locally Advanced Non-Small Cell Lung Cancer

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests whether adding a bispecific antibody to chemotherapy before surgery helps treat advanced lung cancer better than a standard antibody. It is for people with stage II-III non-small cell lung cancer who have not had treatment yet.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
160 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have been diagnosed with non-small cell lung cancer at stage II or III.
  • You have not had any prior treatment for lung cancer, including surgery, radiation, or chemotherapy.
  • You are generally healthy enough to undergo surgery.
  • You do not have certain genetic mutations (EGFR or ALK) if your cancer is adenocarcinoma.
  • You are willing to use effective birth control during the study and for 120 days after treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07863999Recruiting· Phase 3
Immunotherapy before surgery for stage II-III lung cancer

This trial compares two different drug combinations given before surgery for stage II-III non-small cell lung cancer (NSCLC). Both combinations include chemotherapy, and one also includes a newer type of immunotherapy. The goal is to see which approach shrinks tumors more effectively before surgery.

Shanghai, China
NCT07309952Recruiting· Phase 2
Chemo, immunotherapy and targeted radiation before surgery for advanced lung cancer

This trial tests a new approach for people with certain advanced non-small cell lung cancer (NSCLC) that has spread to lymph nodes in the chest but might still be removed. It combines a short course of high-precision radiation, immunotherapy (sintilimab), and standard chemotherapy before surgery to see if it can improve outcomes.

Guangzhou, Guangdong
NCT05429463Recruiting· Phase 3
Surgery-ready lung cancer treatment with immunotherapy plus chemo

This trial studies adding an immunotherapy drug (sintilimab) to standard chemotherapy before surgery for resectable squamous non-small cell lung cancer. It aims to shrink the tumor and improve outcomes, while still keeping the cancer operable.

Hangzhou, Zhejiang
NCT07410975Recruiting· Phase 2
Immunotherapy and chemo before surgery for lung cancer

This trial tests combining two immunotherapy drugs (anti-CTLA-4 antibody and sintilimab) with chemotherapy before surgery for stage II-III non-small cell lung cancer. The goal is to see if this approach helps shrink tumors and improve outcomes.

Shanghai, Shanghai Municipality
NCT06620822Not yet recruiting· Phase 2
Immunotherapy after surgery for lung cancer

This trial tests whether giving more immunotherapy after surgery can help people with non-small cell lung cancer who still had some cancer cells left after their first round of immunotherapy and chemotherapy before surgery. It aims to improve outcomes for those whose tumor didn't fully disappear.

Shanghai, Shanghai Municipality
NCT06946836Not yet recruiting· Phase 2
Comparing two drug combos before lung cancer surgery

This trial compares two treatments given before surgery for early-stage non-small cell lung cancer with high PD-L1. One group gets a new drug called cadonilimab, and the other gets a standard chemo plus an immunotherapy drug. The goal is to see which approach works better at shrinking tumors before surgery.

Hear when a new Locally Advanced Non-Small Cell Lung Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.