Testing a new GVHD prevention method after donor stem cell transplant
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a new way to prevent graft-versus-host disease (a common side effect of stem cell transplant) using a drug called cyclophosphamide after transplant. It is for adults with certain blood cancers who need a transplant from a partially matched unrelated donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older (age limits depend on which type of chemotherapy or radiation you need before transplant).
- You have a blood cancer such as acute leukemia, chronic myeloid leukemia, myelodysplastic syndrome (MDS), chronic lymphocytic leukemia (CLL), lymphoma, or another eligible type.
- Your blood cancer is under good control—no blast cells in your bloodstream and few blast cells in your bone marrow.
- A partially matched unrelated donor (ages 16–35) is available, and you do NOT have a perfectly matched related or unrelated donor.
- Your heart, kidneys, lungs, and liver work well enough based on recent tests.
- You have not had a prior stem cell transplant from another person.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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