Stem cell transplant from a matched sibling for blood disorders
Treatments studied
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests whether a stem cell transplant from a fully matched sibling donor can help people with serious blood disorders like sickle cell disease or thalassemia. It aims to replace the faulty blood system with a healthy one from the donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have sickle cell disease, severe thalassemia, Diamond-Blackfan anemia, or another non-cancerous blood disorder.
- For sickle cell disease: you need a brother or sister who is a perfect genetic match and willing to donate stem cells.
- You should be in reasonably good health overall, able to do most daily activities (score of 60% or higher on a wellness scale).
- If you or your partner can become pregnant, you must agree to use effective birth control during the study and for at least 4 months after transplant.
- You cannot be pregnant, breastfeeding, or planning pregnancy during the study.
- You must not have an active, uncontrolled infection; HIV that is well-controlled may be allowed after evaluation by an infectious disease specialist.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial studies a stem cell transplant approach for children with sickle cell disease, using a sibling donor whose blood type is not compatible. It aims to see if this transplant method can safely reduce serious sickle cell complications.
This trial tests whether a stem cell transplant from a partially gene-matched family member can cure severe sickle cell disease in children and young adults. The transplant uses a new approach that may work even when a perfectly matched sibling isn't available, and it might help patients whose sickle cell is causing serious complications like strokes, organ damage, or frequent pain crises.
This study tests a way to do a bone marrow (stem cell) transplant from an HLA-matched sibling in children with sickle cell disease, aiming to lower the risk of serious side effects. You may be considered if you have certain past sickle complications and your body can safely handle the transplant plan.
This trial is testing a new, gentler type of bone marrow transplant for children and young adults with sickle cell disease who have a healthy sibling donor with a mismatched blood type or who have antibodies against their donor's red blood cells. The goal is to replace the faulty bone marrow with healthy donor cells, with fewer side effects than traditional transplants.
This study tests a partial stem cell transplant from a matched donor to treat sickle cell disease. It may help reduce complications like strokes, organ damage, or pain crises.
This Phase 2 study tests a “half-matched” stem cell transplant to treat people with aggressive sickle cell disease. It may help by replacing the blood system using stem cells from a related donor who is close but not fully matched.
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