Clinical trials
Graft Failure clinical trials
Below are recruiting graft failure clinical trials, each written for real people, not researchers. We’re tracking 35 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06512545Recruiting
Modified second stem cell transplant for graft failure
This study tests a modified second stem cell transplant for people whose first transplant failed. It uses half-matched (haploidentical) donor cells to try to restore healthy blood cells and treat the cancer.
Beijing, Beijing MunicipalityAges 14 years+ - NCT02161783Recruiting
Second transplant for blood stem cell graft failure
This trial studies treatment after a first stem cell transplant fails to produce lasting blood recovery. It may help people who need a second transplant because their counts never fully recovered or then dropped again.
Minneapolis, MinnesotaAges Any age - NCT06512519Recruiting
Second stem cell transplant for graft failure
This trial tests a second transplant using a half-matched donor for people whose first transplant failed. It may help if you have a blood cancer and are otherwise healthy enough for another procedure.
Beijing, Beijing MunicipalityAges 14 years+ - NCT06569082Recruiting
Stem cell boost for poor graft function
This study tests whether giving extra stem cells from your original donor can help your blood cell counts recover after a transplant. It is for people whose new immune system has not fully engrafted or whose counts are dangerously low.
New York, New YorkAges 18 years+ - NCT06676696RecruitingPhase 4
Stopping immunosuppression after failed kidney transplant
This study compares what happens when patients with a failed kidney transplant (still in the body) stop their immunosuppressant medicines at 6 months versus continuing them. The goal is to safely prevent your immune system from becoming too sensitive, which can make finding a new donor kidney harder.
BarcelonaAges 18 years+ - NCT06800430Recruiting
Studying graft problems after bypass surgery
This study looks at why some bypass grafts fail over time. It may help find better ways to treat or prevent graft problems in people who have had coronary artery bypass surgery.
Edinburgh, MidlothianAges 18 years+ - NCT06802926RecruitingPhase 4
Colchicine to prevent graft failure after bypass surgery
This study tests whether a low dose of colchicine, an anti-inflammatory drug, can help prevent the graft (new blood vessel) from failing after heart bypass surgery. It's for people who just had a bypass and are still in the hospital.
ShanghaiAges 18 years+ - NCT04772768Recruiting
Checking problems in vein bypass grafts in people with recurring chest pain
This study looks at how vein bypass grafts are working over time in people who had heart bypass surgery and now have recurring angina (chest discomfort). It may help doctors better understand why symptoms come back and how the heart and grafts change.
AmsterdamAges 18–90 - NCT06235892RecruitingPhase 3
Lowering Tacrolimus for Low-Risk Kidney Transplant Patients
This trial tests whether safely lowering the dose of tacrolimus—an anti-rejection drug—can still protect a kidney transplant one year after surgery. It's for first-time transplant recipients with low immune risk.
NantesAges 18 years+ - NCT06179329Recruiting
Comparing two types of heart bypass grafts in women
This trial compares two types of grafts (the radial artery from the arm and a vein from the leg) used in women having heart bypass surgery for the first time. It aims to see which graft works better and stays open longer.
São Paulo, São PauloAges 18–75 - NCT05285878Enrolling by invitationPhase 2
Fingolimod to protect kidney function after kidney transplant
This trial tests whether fingolimod can reduce kidney scarring and preserve kidney function after a new kidney transplant. It focuses on people who are in the early period after transplant who may be at risk for scarring in the kidney.
Houston, TexasAges 18–65 - NCT07531966Recruiting
Blood Vessel Problems After Kidney Transplant Treatment
This study looks at treating narrowing or blockage of blood vessels in transplanted kidneys. If your transplanted kidney is showing signs of not working well and imaging shows a blocked vessel, this trial tests whether a procedure called angioplasty (opening the vessel with a tiny balloon) can help restore blood flow and improve kidney function.
AarhusAges 18 years+ - NCT07265349RecruitingPhase 1/Phase 2
Stem cells plus bypass surgery for chronic heart failure
This trial tests whether injecting stem cells from umbilical cord tissue into the heart muscle during bypass surgery can improve heart function in people with chronic heart failure. It is for patients who are already scheduled for bypass surgery and have a weakened heart pump (LVEF between 21% and 40%).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07244419RecruitingEarly Phase 1
Preventing stem cell transplant rejection in children
This early-phase trial tests a medication to prevent rejection of donated stem cells in children. It's for patients who are at high risk for their transplant to fail.
Cincinnati, OhioAges Any age - NCT07671235Recruiting
Comparing graft options for repeat ACL surgery
This study compares two types of tissue grafts (your own or a donor's) used in a second ACL knee surgery to see which leads to better outcomes and fewer failures over at least two years.
Bologna, BolognaAges 18–50 - NCT06532890Recruiting
Using microRNAs to personalize heart transplant medicines in children
This study is looking at heart transplant children (up to age 18) to see if measuring tiny molecules called microRNAs in the blood can help doctors personalize anti-rejection medicines. It aims to improve how we prevent rejection while reducing side effects.
Aurora, ColoradoAges Up to 18 years - NCT03541889RecruitingPhase 1
Tracking blood stem cell transplant success with special imaging
This study uses a safe PET scan–type imaging test to look for signs that a stem cell transplant has “taken” (engrafted). It may help doctors understand why some transplants fail and how to improve chances of success.
Atlanta, GeorgiaAges 4–80 - NCT06939751Recruiting
Testing microRNA levels to personalize heart transplant care
This trial is studying whether a blood test that measures small molecules called microRNAs can help doctors personalize the medicines used to prevent rejection after a heart transplant. If you qualify, you would help researchers learn how to better match immunosuppression to each patient's needs.
Los Angeles, CaliforniaAges 18–99 - NCT05084768Recruiting
Test blood markers to predict kidney transplant rejection
This study looks at special blood tests to help predict when kidney transplant rejection might happen. If the markers work, they could help doctors catch rejection earlier and adjust treatment sooner.
Loma Linda, CaliforniaAges 18 years+ - NCT06398457RecruitingEarly Phase 1
Darzalex Before Stem Cell Transplant for High-Risk Graft Failure
This trial tests giving a drug called Darzalex Faspro before the usual desensitization and a stem cell transplant for people at high risk of graft failure due to donor-specific antibodies. The goal is to prevent the transplant from failing.
Baltimore, MarylandAges 18 years+ - NCT06872333RecruitingPhase 2
Stem cell transplant from a matched sibling for blood disorders
This trial tests whether a stem cell transplant from a fully matched sibling donor can help people with serious blood disorders like sickle cell disease or thalassemia. It aims to replace the faulty blood system with a healthy one from the donor.
Minneapolis, MinnesotaAges Up to 55 years - NCT07252050RecruitingPhase 1/Phase 2
Ruxolitinib and half-matched transplant for severe sickle cell disease
This trial tests a new approach using the drug ruxolitinib to help a half-matched bone marrow transplant work better for people with severe sickle cell disease. It aims to reduce complications and improve outcomes.
Aurora, ColoradoAges 12–45 - NCT06422871Recruiting
Observing HeRO Graft and Super HeRO in dialysis patients
This study is tracking how well the HeRO Graft and Super HeRO work for people on dialysis. If you already have one of these devices, joining helps doctors see how it performs over time.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07601867Recruiting
Dapagliflozin to improve heart function after bypass surgery
This trial tests whether a diabetes medication called dapagliflozin can help improve how well the right side of your heart works after off-pump coronary artery bypass grafting surgery (a way to reroute blood around blocked heart arteries). The goal is to see if this drug reduces strain on your heart during recovery.
Pyatigorsk, Stavropol KrayAges 18 years+
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Common questions
- Are there clinical trials for graft failure?
- Yes. Clin2 currently lists 35 recruiting graft failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a graft failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a graft failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.