Adding D-serine to TMS for depression
Part of Brain & nervous system, Mental health clinical trials.
This trial tests whether adding a medication called D-serine to a brain stimulation treatment (TMS) helps improve depression. It’s for adults with major depression who are already getting TMS therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 to 80 years old
- You must have a diagnosis of major depression
- You must be able to swallow pills
- You must not have any metal implants or devices in your body (like a pacemaker or metal plate)
- You must not have had a seizure or been diagnosed with epilepsy
- You must not have kidney disease or an allergy to D-serine
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of transcranial magnetic stimulation (TMS) for people with severe depression that hasn't improved with multiple medications or therapy. It uses a different frequency pattern to target brain circuits.
This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.
This study tests whether adding an experimental medication to a newer type of TMS brain stimulation can improve depression symptoms. It aims to find a new treatment option for people who haven't fully responded to standard care.
This early-stage study tests a type of magnetic brain stimulation called theta burst stimulation combined with study medications to help treat moderate to severe depression. Researchers want to understand how this combination affects brain communication and may help reduce depressive symptoms.
This trial tests a single day of ultra-accelerated brain stimulation (TMS) combined with a single dose of a study drug (NRX-101) to see if it can quickly reduce depression symptoms. It is an early-phase study, meaning the treatment is new and being tested for safety and effectiveness.
This study uses a special type of brain stimulation (rTMS, which uses magnetic pulses) to treat depression. It focuses on part of the brain called the orbitofrontal cortex and aims to understand how stimulating it helps improve mood.
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.