Wire-guided treatment for leg artery disease
Part of Heart & circulation clinical trials.
This trial tests if using a special pressure-sensing wire during treatment of blocked leg arteries below the knee can improve outcomes for people with severe circulation problems that threaten the limb. It aims to help patients with Rutherford category 5 chronic limb threatening ischemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe circulation problems in your leg that put your limb at risk (Rutherford 5).
- The blocked artery in your lower leg (anterior or posterior tibial artery) has a blockage at least 10 cm long.
- You are 19 years or older.
- You do not have a sudden blockage (acute limb ischemia).
- You can take blood thinners safely (no recent bleeding or low platelet count).
- If you are a woman, you are not pregnant or planning to become pregnant.
- Your life expectancy is more than one year.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new way to restore blood flow in the lower leg for people with chronic limb-threatening ischemia, a serious condition where leg wounds won't heal due to poor circulation. If it works, this treatment could help save the leg and avoid amputation.
This trial tests a special balloon that releases medicine to open blocked arteries below the knee in people with severe leg pain or wounds. It may help improve blood flow and avoid amputation.
This trial tests whether using a special ultrasound probe inside the arteries (called IVUS) during a procedure to open blocked vessels below the knee can improve outcomes for patients with critical limb ischemia — a serious lack of blood flow that causes pain, sores, or gangrene. If you qualify, the procedure may help heal your wounds and relieve pain.
This study tests whether using a special ultrasound probe inside the artery during a leg procedure helps doctors open blockages more safely and effectively. It aims to improve blood flow and save the leg for people with severe peripheral artery disease who have pain, wounds, or gangrene.
This trial tests whether a drug-coated balloon can better reopen blocked arteries in the lower leg (below the knee). It may help keep blood flow open and reduce the chance the blockage comes back, after a procedure to cross and open the narrowed area.
This trial uses a special balloon (Shockwave IVL) to break up calcium in leg artery blockages, improving blood flow and reducing pain. It's for people with moderate to severe calcium buildup in the femoropopliteal artery.
Hear when a new Chronic Limb-Threatening Ischemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.