Clinical trials
Chronic Limb-Threatening Ischemia clinical trials
Below are recruiting chronic limb-threatening ischemia clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06311773Enrolling by invitation
Testing the Boomerang Catheter for severe leg artery disease
This trial tests a new device called the Boomerang Catheter for people with severe leg artery disease (CLTI) who have no other treatment options to save their limb. The goal is to see if this catheter can restore enough blood flow to help the leg heal.
San Bernardino, CaliforniaAges 18 years+ - NCT03622359Recruiting
Imaging blood flow in leg artery disease using a scan
This study uses a special “radiotracer” scan to look at how well blood flows through the arteries in the legs. It may help researchers better understand circulation problems from peripheral artery disease.
Columbus, OhioAges 18 years+ - NCT07536373RecruitingPhase 3
Colchicine to prevent amputation after leg artery treatment
This study tests whether a medication called colchicine can help prevent amputation in people with severe leg blood flow problems who just had surgery or a catheter procedure to restore blood flow. Colchicine is an anti-inflammatory drug that may help protect the leg tissue after treatment.
Taipei, TaipeiAges 18 years+ - NCT05055297Recruiting
Drug-coated balloon for severe leg artery blockage in lower legs
This trial studies a “drug-coated balloon” procedure to improve blood flow in people with severe, long-lasting poor circulation in the lower leg arteries. It may help reduce repeat blockage after treatment for selected artery lesions below the knee.
Chandler, ArizonaAges 18 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT05786001Recruiting
Test noninvasive checks of blood flow in limb-threatening ischemia
This study uses painless, noninvasive tests to measure blood flow in people with chronic limb-threatening ischemia. It may help doctors better understand circulation problems and track blood flow without procedures.
Tampere, PirkanmaaAges 18 years+ - NCT06071429Recruiting
Dissolvable medicine stent for leg artery disease
This trial tests a new dissolvable stent that slowly releases medicine to keep your lower-leg artery open. It is for people with severe leg pain or small wounds due to poor blood flow, and who are not eligible for other stents.
New York, New YorkAges 18 years+ - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT06082466Recruiting
Comparing two types of leg bypass surgery
This study compares two types of bypass surgery for blocked leg arteries. One uses a standard vein from your own body, and the other uses a vein supported by a special metal frame. The goal is to see which works better and lasts longer.
SalzburgAges 18 years+ - NCT06111599Recruiting
Thermovision-guided lumbar nerve block for severe leg pain
This trial tests a procedure called a lumbar sympathetic block (a numbing injection around nerves in your lower back) guided by a special heat-sensing camera. It aims to improve blood flow and reduce severe leg pain caused by chronic limb-threatening ischemia.
KošiceAges 20–80 - NCT06263322Recruiting
Recovery tracking after leg artery surgery
This study tests a mobile app to track your recovery after surgery for severe leg artery disease. The goal is to see if using the app helps improve your recovery and quality of life.
Gainesville, FloridaAges 60–100 - NCT06264843Recruiting
Peripheral bypass quality check study
This trial is testing a new way to check the quality of leg bypass surgery while you're still in the operating room, using a special device. It may help ensure the bypass is working well right away, which could reduce the risk of future problems.
San Francisco, CaliforniaAges 18 years+ - NCT06277362Recruiting
New Leg-Saving Treatment for Critical Limb Ischemia
This study tests a new way to restore blood flow to the leg in people who have wounds or dead tissue on their foot and have run out of other treatment options. It's for those who have already tried angioplasty twice without success or have severely hardened small arteries.
Ancona, AnconaAges 18 years+ - NCT06879561Recruiting
Wire-guided treatment for leg artery disease
This trial tests if using a special pressure-sensing wire during treatment of blocked leg arteries below the knee can improve outcomes for people with severe circulation problems that threaten the limb. It aims to help patients with Rutherford category 5 chronic limb threatening ischemia.
SeoulAges 19 years+ - NCT06979284Recruiting
Ultrasound inside artery for severe leg blockages
This trial tests whether using a special ultrasound probe inside the artery (called intravascular ultrasound) helps guide treatment for people with severe leg artery blockages that cause pain, wounds, or gangrene. The goal is to see if it improves blood flow and saves the leg.
HamiltonAges 18 years+ - NCT07330635Recruiting
Chronic wounds and blood circulation checkup
This study checks how well blood flows in the legs of people with and without chronic wounds or circulation problems. It may help doctors better understand and treat poor circulation.
TaipeiAges 20–95 - NCT07352800RecruitingPhase 2
Study of APAC for peripheral artery disease and severe leg ischemia
This trial tests a new drug called APAC to see if it safely prevents blood clots and improves blood flow in people with narrowed leg arteries. It may help those with severe symptoms like pain at rest or non-healing wounds, or those with claudication (leg pain when walking).
HelsinkiAges Up to 85 years - NCT07672249Recruiting
Study on iliac stenting to prevent major leg events
This study looks at people with narrowed or blocked arteries in the pelvis (iliac arteries) who receive a stent to improve blood flow. It aims to understand which factors might predict future serious problems in the legs, like worsening pain or amputation.
Milan, MiAges 18 years+ - NCT06421961Enrolling by invitation
AI smartphone app for monitoring leg ulcers in PAD
This study tests a smartphone-based tool that uses artificial intelligence to help monitor hard-to-heal leg ulcers caused by poor arterial blood flow. The goal is to see if the tool can accurately assess wound healing at home.
GothenburgAges 18 years+ - NCT04433572RecruitingPhase 3
Temsirolimus treatment to improve below-knee artery procedures
This trial studies whether delivering a medicine called temsirolimus directly into the artery during a below-knee revascularization procedure can improve blood flow and outcomes. It may help people with severe leg artery disease who have symptoms like pain while walking or threatened limb tissue loss.
Houma, LouisianaAges 18 years+ - NCT06204237RecruitingEarly Phase 1
PET imaging safety study for leg artery disease patients and healthy volunteers
This study tests whether a new radioactive tracer called APAC is safe and can be seen in PET/CT scans. It is for people with blocked leg arteries (PAOD/CLI) and for healthy volunteers. The goal is to see where the tracer goes in the body and how the body tolerates it.
GroningenAges 40–85
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Chronic Limb-Threatening Ischemia trials by city
Studies with a site in or near these metro areas.
Chronic Limb-Threatening Ischemia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for chronic limb-threatening ischemia?
- Yes. Clin2 currently lists 21 recruiting chronic limb-threatening ischemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic limb-threatening ischemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic limb-threatening ischemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.