Adebrelimab plus chemo with or without radiation before breast cancer surgery
Part of Cancer clinical trials.
This trial tests adding a drug called adebrelimab to standard chemotherapy and possibly radiation, given before surgery for breast cancer that is HER2-negative and locally advanced. The goal is to see if this combination helps shrink tumors more effectively, potentially allowing for breast-conserving surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman between 18 and 70 years old.
- You have HER2-negative invasive breast cancer that is stage II or III.
- Your breast tumor is at least 5 mm from the skin and not invading the ribs or chest muscles, so it can be treated with precise radiation.
- You have not had prior chemotherapy, immunotherapy, or radiation to the chest.
- Your blood counts, kidney, and liver function are at a certain level, and you can have an MRI.
- You are not pregnant, not breastfeeding, and using birth control if you could become pregnant.
- You do not have active autoimmune diseases like lupus, rheumatoid arthritis, or Crohn's disease (except for stable thyroid conditions, type 1 diabetes, or skin conditions like psoriasis).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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