Esketamine with pulse radiofrequency for shingles nerve pain in face
Treatments studied
Part of Brain & nervous system, Pain clinical trials.
This trial tests whether adding esketamine (a fast-acting pain medicine) to a standard nerve treatment called pulse radiofrequency (PRF) can better relieve lasting facial pain from shingles. It may help people who still have pain in the face or head after shingles.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have had pain in your face or head for more than three months after a shingles rash.
- Your pain is rated at least 4 on a 0-to-10 scale (0 = no pain, 10 = worst pain).
- You are already scheduled to receive a CT-guided procedure called PRF on a facial nerve bundle (gasserian ganglion).
- You do not have sleep apnea, serious medical conditions (like heart, liver, or kidney problems), immune disorders, cancer, or a history of drug abuse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding esketamine (a medicine related to ketamine) to a standard nerve treatment (pulsed radiofrequency) can better relieve face pain caused by shingles. It may help if you have ongoing, moderate-to-severe pain in your face or scalp.
This study tests a combination of a nasal spray medicine (esketamine) and a nerve treatment (pulsed radiofrequency) to reduce severe shingles pain. It may help people who have had shingles pain for less than 3 months and are already scheduled for the nerve procedure.
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This trial tests an intravenous medicine called dexamethasone palmitate for people with shingles pain on the face (trigeminal nerve area). It aims to see if it can safely reduce severe pain during the acute and subacute phases.
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