Study of CYH33 for PIK3CA-related overgrowth and vascular malformations
Part of Blood & lymphatic, Genetic & congenital clinical trials.
This trial tests a new drug called CYH33 for people with conditions caused by a specific gene mutation (PIK3CA) that leads to abnormal tissue growth or blood vessel problems. It aims to see if the drug is safe and can help shrink or control these growths.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or your legal guardian) must sign a consent form agreeing to participate.
- Adults must be 18 or older; teens must be at least 12 and weigh 88 pounds or more.
- You must have a confirmed PIK3CA gene mutation and at least one measurable growth or vascular malformation.
- Your organs and bone marrow must be working well enough, as checked by tests.
- You cannot have had certain treatments (like mTOR inhibitors) in the last 28 days or any other PROS/PRVM treatment in the last 8 weeks.
- You must not have taken any PI3K inhibitor drug before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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