Personalized osimertinib treatment guided by blood test for EGFR lung cancer
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a personalized treatment plan for advanced lung cancer with an EGFR mutation. It uses a blood test (ctDNA) to guide treatment with osimertinib (a targeted pill) plus chemotherapy. The goal is to see if adjusting therapy based on the blood test results can help you live longer with fewer side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have a new diagnosis of advanced (stage IIIB/IV) or recurrent non-small cell lung cancer that cannot be surgically removed.
- Your tumor has an EGFR mutation (exon 19 deletion or L858R).
- The EGFR mutation can be detected in your blood (liquid biopsy).
- You have not taken any EGFR-targeted pills (like osimertinib, erlotinib, or gefitinib) before.
- You have no history of interstitial lung disease (ILD) or drug-related lung inflammation needing steroids.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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